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Ortiz, 37, and her husband Noah Lebenzon, the guitarist for the band Half Life, are expecting the baby at the end of July.
"They are thrilled and ecstatic," says a friend of the New York City-based couple. "They can't wait to be parents."
In September, the actress told PEOPLE she was feeling the itch to have children partly because of the baby boom on the set of her hit show. (Earlier this week costar Rebecca Romijn welcomed twins.)
"It's definitely something that my husband and I talk about all the time," Ortiz told PEOPLE.
• An Ugly Betty Baby Boom! Leave your well wishes for Ana here
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• 2007: Ana & Noah tie the knot in Puerto Rico!
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• Read about more celeb pregnancy announcements on the covers of PEOPLE!
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