The newly-minted first lady was photographed by famed shooter Annie Leibovitz at the Hay-Adams Hotel, where the Obamas stayed before the Inauguration.
While nearly every first lady – beginning with Herbert Hoover's wife, Lou, in 1929 – has been photographed for the fashion bible, only Hillary Clinton was featured on the cover, in Dec. 1998, Vogue spokesman Patrick O'Connell tells PEOPLE.
In the March issue of the magazine, Obama is seen wearing a magenta dress by Jason Wu, who designed her inaugural gown, and also pictured in a black dress by designer Narciso Rodriguez, according to The Washington Post.
"I am thrilled to have dressed Michelle Obama again, this time for the cover of America Vogue," Wu tells Entertainment Tonight Canada.
Future PlansIn the interview, Obama talks about getting used to Washington and her plans for being a first lady – and first mom. "I'm going to try to take [our two daughters] to school every morning – as much as I can," she says, according to the Post. "But there's also a measure of independence. And obviously there will be times I won't be able to drop them off at all. I like to be a presence in my kids' school. I want to know the teacher; I want to know the other parents."
As for why Vogue chose to feature Obama on the cover, the magazine's editor Anna Wintour writes, "Change was the clarion call of Barack Obama's election campaign, though I don't think any of us at Vogue initially realized that would include the difference that was going to be made by First Lady Michelle Obama's wardrobe ... It's inspiring to see our first lady so serene and secure in her personal style."