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Bledel, who starred in the Sisterhood of the Traveling Pants movies and played daughter Rory for seven seasons on TV cult favorite Gilmore Girls, will scrub in as new intern Dr. Julia Wise.
The final episode will mark the 27-year-old's only appearance on the show, which is ending its run April 2 on NBC.
Bledel joins a list of stars scrubbing into ER for the farewell season, including George Clooney, whose episode will air March 12.
JOSH & FERGIE: ROCKED BY SCANDAL
Did he cheat with a stripper?
Married less than a year, the couple denies an Atlanta woman’s claims that she and Josh had a fling
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