Patricia Arquette's second directing stint for her NBC series Medium will be a star-studded affair – she is tapping friend Balthazar Getty, along with Rumer Willis and Anjelica Huston, for a gripping episode about past demons and future consequences, PEOPLE has learned.
Huston will reprise her Emmy nominated role as Cynthia Keener, a private investigator now serving prison time for the murder of her daughter's killer.
In the episode, entitled "The First Bite is the Deepest," Huston's character reaches out to Arquette for help when a friend, played by Willis, goes missing. Simultaneously, Arquette is asked by a wealthy real estate magnate (Getty) to investigate the case of his missing wife.
The episode, which begins shooting this week, will air in the spring.