08/27/2009 AT 11:45 AM EDT
Parker Posey is known for her feisty screen roles, but she has recently been knocked down by an illness.
A statement released Wednesday by Playwrights Horizons
said that Posey would not be able to perform in the new stage production of This
"due to developing a case of Lyme disease."
The actress, who has starred in movies such as Best in Show
, Waiting for Guffman
and Dazed and Confused
, was set to play the lead in the production, which starts previews Nov. 6.
A replacement for Posey, 40, in the comedy will be announced shortly, according to Playwrights Horizons.– Marla Lehner