The actress, 58, has signed on to star in a new reality series for A&E, which will follow her as she juggles trying to lose weight with life as a single mom to two teenagers in Hollywood.
The untitled show, which will run for 10 half-hour episodes, is scheduled to debut sometime next year.
"Kirstie is exactly the kind of star A&E is drawn to," said A&E nonfiction/alternative programming senior VP Robert Sharenow. "Her personal life has been playing out in the media for years, but this will be the first time she'll be opening up her home to reveal her real life for the cameras."
While the actress has talked about her weight issues on TV before and starred in the 2005 scripted Showtime series Fat Actress, this marks her first foray into reality television.
In May, Alley told PEOPLE that while she had gained 83 lbs., she had a plan to get her life back on track: "I'm gonna go, 'You know what? Get back on the horse, lose the freakin' weight, and then just move forward!' "