Both pictures are up for best feature film, and will compete in the category with (500) Days of Summer, Amreeka, and Sin Nombre
Lee Daniels, who directed Precious, and Michael Hoffman, who helmed The Last Station, were both nominated for best director. Mo'Nique, who has been hailed for her role as the brutal mother in Precious received a nod for best supporting female.
A Serious Man was selected for the Robert Altman Award, which is given to one film's director, casting director and ensemble cast.
The ceremony will be held on Friday, March 5, in a tent on the event deck at L.A. Live. The show will air live on the cable channel IFC.
For complete list of nominations, visit SpiritAwards.com