Taylor Lautner, Ryan Reynolds and Carrie Underwood are among the celebrities expected to attend. A record 60 million-plus fan votes have been counted, according to producers.
New categories this year include favorite Web celeb, which features nominees Andy Samberg, Ashton Kutcher, Miley Cyrus, Diddy and Will Ferrell, as well as favorite on-screen team, in which the Twilight trio of Lautner, Robert Pattinson and Kristen Stewart will compete against The Proposal's Reynolds and Sandra Bullock, among others.
Charlie Sheen is among the five nominees for favorite TV comedy actor.
The show airs from the Nokia Theatre in Los Angeles at 9 p.m. ET on CBS.