The Scrubs star and fiancé Jamie Afifi, an entertainment lawyer, welcomed son Charlie Rhodes Afifi on Christmas Eve, her rep confirms to PEOPLE exclusively.
The baby boy is the first child for the actress, 33, and Afifi, 36, who were engaged in Dec. 2006. The couple announced the pregnancy in August.
Charlie will have some company in the Scrubs nursery – Chalke's costar Judy Reyes welcomed daughter Leila Rey in November.
Reporting by JULIE JORDAN