The Blind Side star beat out stiff competition, including Jennifer Aniston and Kristen Stewart, to be named favorite movie actress at the 36th Annual People's Choice Awards, televised live from L.A.'s Nokia Theatre Wednesday.
No stranger to the ceremony – this marks the star's fifth win for favorite movie actress since her first nomination in 1996 – Bullock, 45, was a double winner Wednesday night: Her film The Proposal, costarring Ryan Reynolds, was named favorite comedy.
"I am only up here because I am fortunate to work with people who make me look good," a tearful Bullock said while accepting her award. "[Thanks] most of all to my family . . . Life is hard sometimes, but we get through with laughter."
The actress also acknowledged her fans. "Thank you to everyone who voted," she said, "because you're voting for all the people who make me look good – and you're making me look very good."
Otherwise, it was Twilight-mania at the Nokia Theatre, where voters didn't forget about the blockbuster. The teen vampire flick swept the award show, claiming four trophies in total, including favorite movie, favorite on-screen team (an award given out to the entire cast) and favorite franchise. Meanwhile, Taylor Lautner was awarded favorite breakout actor as the series' sexy werewolf, Jacob Black.
The vampire craze made its way to the television screen too, as HBO's True Blood sucked up the favorite TV obsession award.
Music to Their EarsIn music news, Taylor Swift continued her recent award show sweep, nabbing favorite female artist, while fellow country star Keith Urban won favorite male artist.
And newly engaged Carrie Underwood had plenty to smile about, too. The singer, who picked up three awards last year, was named favorite country artist for the second year in a row.
Other major winners included Lady Gaga, who won favorite breakout music artist and favorite pop artist. Johnny Depp won favorite movie actor, while Miley Cyrus won breakout movie actress.
Going OnlineFor the first time this year, fans voted in the new category favorite Web celeb – which went to Twitter guru Ashton Kutcher.
Over 60 million fan votes were counted, according to producers, which determined the winners. Queen Latifah emceed the proceedings, which marks the kick-off of awards-show season in Hollywood.
For a full list of winners, visit the People's Choice Awards' official Web Site.