Oprah Winfrey

UPDATED 12/28/2009 at 01:00 AM EST • Originally published 12/28/2009 at 01:00 AM EST

Really, what didn't Oprah do in the past decade? The daytime host expanded her empire to include movies, radio shows, Broadway, a magazine, her own network and the Oprah Winfrey Leadership Academy for Girls in South Africa. But it's the daily dose of "O" that 7 million viewers will miss most when she retires her show. "We're talking about someone whose contributions are not only enormous," says pal Robert Iger, CEO of the Walt Disney Corporation, "they have touched everybody in such unique ways."