Reid appeared last on NBC's hit show in December of 2007. She also had roles on As the World Turns and The Edge of Night.
"I'm so sad to hear the news about Frances Reid," Tweeted actress Alison Sweeney, who plays Sami on Days. "She was a truly talented actress and we are all lucky and proud to have known her."
Reid played the silver-haired, mild-mannered matriarch of the show’s Horton clan since 1965 – a role she initially turned down.
Born in Wichita Falls, Texas, Reid was raised in Berkeley, Calif., and later moved to New York to pursue her acting career on the stage. She landed roles in Cyrano de Bergerac, Hamlet and Twelfth Night.
Her character on Days was seemingly killed off by the show’s Salem Stalker in 2004, but it turned out to be a hoax and she returned later the same year.
Reid won the Daytime Emmy's Lifetime Achievement Award in 2004 and was married to late actor Philip Bourneuf for 43 years. She had no children.