O'Donnell is targeting fall 2011 for the debut of her new vehicle – around the same time that Oprah Winfrey will take her final bow on The Oprah Winfrey Show.
The comedian, 48, is no stranger to the daytime airwaves. The talk show vet hosted the Emmy-winning Rosie O'Donnell Show for six years before her gig on The View.
Since last fall, O'Donnell has been reaching fans via her daily, two-hour show on Sirius XM Radio called "Rosie Radio." But she never abandoned TV altogether: In January, she debuted her HBO documentary A Family Is a Family Is a Family: A Rosie O'Donnell Celebration, which highlights different family dynamics.