"She's my fairy godmother," Lopez said in an interview that aired on E!'s Daily 10 Thursday night. "She knows how much I care about her. And, you know, when times are tough, friends step up."
Added the Lopez Tonight host: "She's a beautiful person, and when she needs friends, of course I'm going to be there." The two have been close since 2000, when Bullock discovered Lopez, who was then a stand-up comic. Two years later, she executive produced his hit television show, George Lopez.
"Sandra Bullock completely gave me life," Lopez told PEOPLE in a 2006 interview.
In recent weeks, Lopez has been spotted at his friend's Hollywood Hills home, paying her visits and giving lurking paparazzi updates on her welfare. ("She's all right," he said after an April 6 visit.) But what would the talk show host say to Bullock's husband, Jesse James, if he saw him on the street?
Nothing, he told E! "Oh, he'd kick my ass," he said. "I can't beat him up. That dude's strong!"