Winfrey spoke Monday at The New York Women in Communications Matrix Awards, where she presented an award to pal Gayle King.
Winfrey skipped the red carpet but wasted no time when she took the stage bashing Kelly's book, which includes reports the daytime diva abused drugs and questions the extent of Winfrey's longtime claim of being sexually abused as a child.
Winfrey described King as a friend who "sometimes cares about my life more than I do," and told the audience last week "was a rough one" for King when a "so-called biography came out."
"Gayle got herself worked out with all my new daddies coming out," said Winfrey of Kelly's claims in the book that Vernon Winfrey is not her biological father.
While the audience responded with loud applause, Winfrey smiled and concluded, "This, too, shall pass."
Praising King before presenting her with her award, Winfrey thanked her longtime confidante for teaching her "what true love really is." Winfrey described King as "her best friend who always wants the best for me" adding, "She's never been jealous or envious of me a single moment of my life except when I was on stage singing with Tina Turner."