"We're bracing ourselves for our next little tornado," Damon told PEOPLE at Thursday night's Save the Children's Celebration of Hope fundraiser in Greenwich, Conn., where he was honored for his work with the organization.
"We're excited," said the actor, 39. "But it is a lot of work."
The Invictus star and his wife, Luciana, 34, wed in 2005 and have two children together – Isabella, 3, and Gia, 21 months. Luciana also has a daughter, Alexia, 11, from a previous marriage.
Damon's award for his efforts helping kids all over the world took place on the same night as the 30 Rock finale, on which he guest-starred as Tina Fey's knight in shining armor, with wings – as a pilot named Carol.
Responding to reports this week that he'll return to the NBC comedy next season, Damon told PEOPLE: "If they'll have me, I would love to pop in and see the gang again. I had a great time doing it. I've worked with Alec Baldwin before, and I am a big Tina Fey fan."