"Best night of my entire life," Vazquez wrote on her Twitter page. "Thank u to all my family and friends who shared tonight with me. I love u. I'm on cloud 9 right now."
Vazquez wore a Vera Wang wedding gown as she exchanged vows with Anthony in a ceremony performed by Dr. Michael Eric Dyson, PEOPLE has learned. Also among the 300 invited guests were Khloe Kardashian and Lamar Odom, Spike Lee, Ludacris and Kelly Rowland.
The couple's 3-year-old son Kiyan served as ring bearer.
The Manhattan venue, featuring towering marble columns and chandeliers, was transformed into a red-themed celebration featuring red table cloths, centerpieces of red Ecuadorian roses, hundreds of candles and thousands of red roses hanging from the high ceiling.
Following the ceremony, the newlyweds joined their guests for cocktails and a sit-down dinner and dancing to a live band. The five-tiered white cake was decorated with red flowers.
Vazquez and Anthony invited their guests with a red and gold wedding invitation decorated with Swarovski crystals. Designed by invitation company Lehr & Black, it was delivered in a black box featuring their first initials.
The couple, who were engaged on Christmas Day 2004, kicked off their wedding weekend on Friday evening with a rehearsal dinner on a boat featuring gambling, cigar rollers, a buffet-style dinner and dancing to a DJ.
The wedding, which was filmed for an upcoming VH1 reality show, was planned by event planner Mindy Weiss.