The former Dawson's Creek star, 33, and Brook were married Sunday in Tel Aviv in "a small spiritual ceremony surrounded by a few close friends and teachers," his rep says in a statement.
For the intimate gathering, Van Der Beek suited up in Armani while his bride wore a vintage creation by Shareen.
"Best day of my life so far," he Tweeted on Sunday, before adding, "The woman I love did me the honor of [becoming] my wife today … I look forward to earning her for the rest of my life."
No word on the honeymoon, but Van Der Beek and Brook have something else to look forward to: Parenthood. They're expecting their first child together and revealed they're having a girl.
Reporting by JULIE JORDAN