Watch a Sneak Peek of The Big Bang Theory!

09/22/2007 AT 12:00 AM EDT

It's revenge of the nerds on fall TV! Watch Johnny Galecki and Jim Parsons use big, impressive words to describe their new CBS sitcom, about two brilliant physicists whose sheltered lives becomes much more interesting when a babe moves next door. And just like her lovable girl-next-door character Penny, Kaley Cuoco (from 8 Simple Rules… for Dating My Teenage Daughter) keeps the guys in check!

Premieres: Monday, Sept. 24, 8:30 p.m. ET

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