She's set to play mom to Julia Roberts in August: Osage County. Here are a few more of her famous "kids."
Renée Zellweger
Zellweger let tears flow for her cancer-ridden mom in One True Thing.
AMANDA SEYFRIED
Streep and Seyfried made a cheeky song-and-dance team in Mamma Mia!
LEONARDO DICAPRIO
A pre-Titanic Leo played her pyromaniac son in Marvin's Room.
LINDSAY LOHAN
Country singers Lohan and Streep duet in A Prairie Home Companion.
Your Reaction
