The actress, who stars as a mom with multiple personality disorder in Showtime's The United States of Tara, and her husband, musician Dave Galafassi, "are very happy to be expecting our second child together," the couple tell PEOPLE exclusively.
The pair – who wed in 2003 – are already parents to daughter Sage Florence, 2½.
Collette, 37, is due next year.
– Julie Jordan
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