"Police responded to a call for an intoxicated male," a source confirms to PEOPLE. Sheen, 45, was taken to the hospital "in the company of a female, unharmed." He was removed from the scene for "for alcohol abuse and psychological evaluation" and considered an "aided case," meaning no arrest was made.
According to Sheen's rep, "What we are able to determine is that Charlie had an adverse allergic reaction to some medication and was taken to the hospital, where is expected to be released tomorrow."
A police source tells PEOPLE, "I believe he was irrational and intoxicated." Sheen was taken voluntarily to New York Columbia Presbyterian Hospital by ambulance.
Police were sent to The Plaza Hotel in midtown New York after a call from hotel security, according to the New York Post. The room was trashed when police responded, including damage to a chandelier and hotel furniture.
Sheen, in addition to being recently rehabbed, less than a month ago walked his daughter down the aisle. The Two and a Half Men star is visiting the city with ex-wife Denise Richards, 39, who accompanied him to the hospital, and their two daughters.
Reporting by LIZ MCNEIL and ANNE MARIE CRUZ