Arquette, who later apologized via Twitter for over-sharing, admitted that Cox was not happy he spoke so candidly about their relationship the day after the two announced their trial separation.
"She got really pissed," Arquette, 39, told Howard Stern Wednesday morning. "We talked it all out and then we took a walk and it was great … She had a right to get upset about some of the personal details."
In his initial interview with Stern, Arquette revealed that Cox, 46, was tired of being his mother and that they haven't had sex in four months.
Wednesday, Arquette admitted to crying following the first time he slept with another woman after 11 years of marriage, "because it was the end of all the intimacy I shared with my wife."
He later addressed rumors that he'd cheated on Cox, explaining that their separation agreement allowed them to see other people. "I was faithful to my wife for 11 years … completely devoted," he said Wednesday on Regis & Kelly.
The actor, who has a 6-year-old daughter, Coco, with Cox, hasn't ruled out the possibility of getting back together with his wife, and hopes some space might help their relationship. "We gotta kind of make this separation more separate ... Just not so easy to communicate," he told Stern.
When pressed by Stern about whether he was ready to move on, Arquette said, "The fact of the matter is that I am still [expletive] in love with my wife – that's the bottom line."