"Charlie is a survivor," Mueller told Extra. "He knows how to handle himself."
She also downplays reports of that night, when Sheen, 45, was found naked in an allegedly trashed room at the Plaza Hotel and was later sent to a New York hospital. "You know how things get blown out of proportion," she added.
Mueller, mother of Sheen's 19-month-old twin sons, has had her own drama with the actor. He was arrested on Christmas Day last year after a fight with Mueller in Aspen, Colo. He later cut a deal and is currently on probation. The couple are living apart but neither has filed for divorce.
After Tuesday's incident, Sheen flew back to Los Angeles and went back to work. He also says reports of his wild night, reportedly spent with porn star Christina Walsh, were "overblown and overplayed."