Sandra Bullock and Kate Middleton are joined on the list by Justin Bieber, Betty White, LeBron James, Sarah Palin, new American Idol judge Jennifer Lopez and the cast of Jersey Shore.
As usual, Walters won't divulge the final names – or the overall Most Fascinating Person – until the special airs Dec. 9 at 10 p.m. EST.
Middleton was a prescient choice, having reportedly been selected for the list before word of her engagement to Prince William broke this month.
Palin, meanwhile, makes a return appearance, having been featured on Walters's 2009 list as well.
Walters has chosen a woman as her overall Most Interesting Person in each of the past five years: Michelle Obama (2009), Tina Fey (2008), J.K. Rowling (2007), Nancy Pelosi (2006) and Camilla Parker Bowles (2005).
Will Lady Gaga make the cut? Who is your top guess for 2010?