Mantegna, 20, the daughter of previous Golden Globe nominee (for The Rat Pack) Joe Mantegna, made her acting debut – alongside her father – at 13 in the 2003 film Uncle Nino.
She's joining the ranks of young starlets like Rumer Willis – daughter of Demi Moore and Bruce Willis – and Mavis Spencer – daughter of Alfre Woodward and Roderick Spencer – who held the title in 2008 and 2010, respectively.
Mantegna has appeared on the Secret Life of the American Teenager and her father's show, Criminal Minds. She also stars in the TeenNick series Gigantic, alongside Grace Gummer, 24, who is the daughter of Meryl Streep.
When the cameras aren't rolling, Mantegna is spending time – or Tweeting about – her beau of more than a year, former Hannah Montana star Mitchel Musso.
The 68th Annual Golden Globe Awards will air live from Beverly Hills on Jan. 16 at 5 p.m. on NBC.