Keeping its momentum from last year, the Twilight saga was the big winner on Wednesday night.
The latest installment in the series, Eclipse, picked up four awards, including favorite movie, surpassing nominees including The Social Network and Inception.
It also won favorite drama movie and favorite on-screen team at the awards at the Nokia Theater in L.A., and star Kristen Stewart beat out Angelina Jolie and Jennifer Aniston for favorite movie actress as Bella Swan.
But the film's heartthrobs Robert Pattinson and Taylor Lautner didn't have as much luck when it came to favorite movie actor, which was awarded to Johnny Depp for Alice in Wonderland.
Pattinson was beat out again in a separate category for favorite movie star under 25, which went to Zac Efron.
Adam Sandler, another popular actor at the show, won for favorite comedic star, while his hit flick Grown Ups was favorite comedic movie.
Eminem continues his successful year, snagging the most awards in the music category. Winning favorite male artist and favorite hip hop artist, the rapper also scored favorite song along with Rihanna for "Love the Way You Lie." The sexy Barbadian songstress also won for favorite pop artist.
House M.D. beat out Glee in the TV category with three awards: favorite TV drama, favorite TV drama actor (Hugh Laurie) and favorite TV drama actress (Lisa Edelstein).
Favorite new TV comedy was Bleep My Dad Says and favorite new TV drama was Hawaii Five-O