The actor, 63, who earned an Emmy nomination as a villain on FX's Damages, is back with the good guys, joining the cast of CBS's CSI: Crime Scene Investigation as the show's chief investigator.
He replaces Laurence Fishburne, who played Dr. Raymond Langston for two years. Fishburne had replaced the show's original star, William Petersen.
"You can create a new character on the page, but until the perfect actor comes along and breathes life into it, it's just words," executive producer Carol Mendelsohn says. "We're very excited Ted Danson came along."
"From the moment we all started talking about the role, it was clear he couldn't be more perfect," adds executive producer Don McGill. "Intelligence, wit, warmth, depth of character and emotion, he brings it all. And now he'll have to bring latex gloves, too."
Danson, perhaps best known for playing Sam Malone on the '80s sitcom Cheers, will remain a series regular on the HBO series Bored to Death.