The Talk's Sara Gilbert, Partner Break Up
The Talk co-host and actress, 36, and Adler, 44, will share custody of their two children, son Levi, 6½, and daughter Sawyer, 4.
Gilbert and Adler, a television producer and writer, began dating in 2001.
A rep for Gilbert confirms the breakup. "It's completely amicable," the rep tells PEOPLE.