Patrice O'Neal Dies at 41
updated 11/29/2011 AT 04:00 PM EST
•originally published 11/29/2011 AT 02:00 PM EST
His death was confirmed via Twitter Tuesday by host Opie (Gregg Hughes) of the Opie and Anthony SiriusXM radio show, on which the stand-up comic was a regular guest. The message read: "Yes it's true that our pal Patrice O'Neal has passed away. The funniest and best thinker i've ever known PERIOD. #devastated."
O'Neal, a 6' 5", 300-plus-lb. native of Boston, also appeared on Late Night with Conan O'Brien and Late Show with David Letterman and the sitcoms Arrested Development and The Office.
In September, O'Neal, whose humor was often confrontational but funny, participated in the Comedy Central roast of Charlie Sheen, where other comedians made fun of his diabetes. It was his last performance.
O'Neal, who launched his career in the late '90s, started out by heckling comics and proving he could do better, according to his Comedy Central bio. His idols were George Carlin and Richard Pryor.
TMZ.com first reported his death.