"This is a personal and private matter for Katie and her family," says Holmes's attorney Jonathan Wolfe. "Katie's primary concern remains, as it always has been, her daughter's best interest."
Cruise's rep tells PEOPLE: "Kate has filed for divorce and Tom is deeply saddened and is concentrating on his three children. Please allow them their privacy."
The Rock of Ages star, 49, wed actress Holmes, 33, in an Italian castle in November 2006. They have daughter Suri, 6.
This was Holmes's first marriage and the third for Cruise, who previously was married to the actresses Nicole Kidman, with whom he has two children, and Mimi Rogers.
For more on the shocking split, follow PEOPLE.com and pick up the next issue of PEOPLE magazine, on newsstands Monday