08/03/2012 at 01:30 PM EDT
For some fans of the Twilight
franchise – also known as Twi-Hards
– news that Kristen Stewart cheated on Robert Pattinson
felt like their own personal heartbreak.
Also offering his tears: Will Ferrell.
"What they had was so special," the comedian, 45, deadpanned to Conan O'Brien on Thursday night's Conan
. (Watch the video below.) "You don't even know what they had. They were in love, and she just threw it all away."
His tongue-in-cheek concerns continued: "I just don't know if there was anything I could have done to prevent it. And I don't know what it means to the Twilight
franchise. I just don't know."
If it brings Ferrell any comfort, the Breaking Dawn: Part 2
costars (and, now, exes) are still set to join
the rest of the cast to promote the final installment of the vampire smash (although sources tell PEOPLE
Pattinson is "heartbroken and angry" with Stewart for her affair with married director
Still, like a scorned lover, Ferrell had some not-so-nice things to say about Stewart, 22 (all in good fun, of course!): "She is a tramp-ire. That's what she is."