Will Ferrell Jokes: Kristen Stewart Is a 'Tramp-ire'

By Alison Schwartz

UPDATED 08/03/2012 at 01:30 PM EDT • Originally published 08/03/2012 at 10:25 AM EDT

For some fans of the Twilight franchise – also known as Twi-Hards – news that Kristen Stewart cheated on Robert Pattinson felt like their own personal heartbreak.

Also offering his tears: Will Ferrell.

"What they had was so special," the comedian, 45, deadpanned to Conan O'Brien on Thursday night's Conan. (Watch the video below.) "You don't even know what they had. They were in love, and she just threw it all away."

His tongue-in-cheek concerns continued: "I just don't know if there was anything I could have done to prevent it. And I don't know what it means to the Twilight franchise. I just don't know."

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If it brings Ferrell any comfort, the Breaking Dawn: Part 2 costars (and, now, exes) are still set to join the rest of the cast to promote the final installment of the vampire smash (although sources tell PEOPLE Pattinson is "heartbroken and angry" with Stewart for her affair with married director Rupert Sanders).

Still, like a scorned lover, Ferrell had some not-so-nice things to say about Stewart, 22 (all in good fun, of course!): "She is a tramp-ire. That's what she is."