03/26/2013 at 07:00 AM EDT
As she continues to proclaim her innocence, Amanda Knox will be retried
for the 2007 stabbing murder of Meredith Kercher, an Italian court ruled on Tuesday.
Knox, an American, and her Italian then-boyfriend Raffaele Sollecito were initially found guilty
of killing Knox's 21-year-old British roommate and spent four years in prison – but that verdict was thrown out
on appeal of the scientific evidence in 2011.
Italy's Court of Cassation has now thrown out the acquittal and ordered a retrial to be held in Florence, Reuters reports. She will not have to appear in Italy as defendants there are not required to be in court.
Knox, now 25, slammed the decision. "It was painful to receive the news that the Italian Supreme Court decided to send my case back for revision when the prosecution's theory of my involvement in Meredith's murder has been repeatedly revealed to be completely unfounded and unfair," she said in a statement.
"I believe that any questions as to my innocence must be examined by an objective investigation and a capable prosecution," she said. "The prosecution responsible for the many discrepancies in their work must be made to answer for them, for Raffaele's sake, my sake, and most especially for the sake of Meredith's family. Our hearts go out to them."
Knox said she and her family would "face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity."
Prosecutors claim Kercher was killed during a drug-fueled sexual assault. She was found with more than 40 wounds and a deep gash in the throat in the Perugia apartment she shared with Knox.
Knox and Sollecito admitted to smoking marijuana on the night Kercher died but said they played no role in her stabbing.
A third person, Rudy Guede of the Ivory Coast, is serving 16 years after being found guilty in a separate trial. Prosecutors believe he could not have killed Kercher by himself.