Berry, 47, will headline Extant, a 13-episode thriller. Berry will play an astronaut trying to reconnect with her family when she returns after a year in outer space. Her experiences lead to events that change the course of history.
The series is being made in partnership with Steven Spielberg's Amblin Television, which made last summer's surprise hit for CBS, Under the Dome.
CBS Entertainment president Nina Tassler said Berry is the type of actress "you dream of collaborating with for an event project such as Extant."
Berry won an Oscar in 2002 for her starring role in Monster's Ball.