Holcombe had applied to Clemson's LIFE program, which is designed for students with special needs. Watching Holcombe open the letter and [SPOILER ALERT] realize that his dream has come true is a moment of true joy. He's going to be a college student and a Clemson Tiger; life is full of possibility and opportunity for Holcombe. One can't help but smile (and tear up) along with him.
In the YouTube comments, his mother Susan Holcombe writes, "I love that kids like Rion get to experience college life and this type of independence. Proud of my alma mater!"