"She's very tiny, in height…. It seems like she had had a baby and said, 'I don't really give a s–––' … I read it on her gut," Mohr, 43, said about Milano's appearance at the Nascar Spring Cup Series Awards gala he hosted in Las Vegas on Dec. 6.
"Somebody sat in the director's chair was not wearing Spanx and I was like 'Jesus Christ!' " he continued.
Milano, 41, who is mom to 2-year-old son Milo, took the high road. "So sorry you felt the need to publicly fat-shame me. Be well and God Bless. Please send my love to your beautiful wife," the Mistresses star replied.
After fans rallied to her defense, Milano Tweeted her gratitude. "You're all lovely. Thank you for your kind words. #Appreciative."
Mohr, who also welcomed a son in 2011 with wife Nikki Cox, offered a Twitter mea culpa of sorts after the fallout.
"She's stunning. I mistakenly thought the absurdity of what I was saying would have [been] taken as a joke. #fail," he Tweeted.
In addition to Thursday's Tweet, Mohr also posted a longer apology on his blog Friday afternoon.
"I will not make excuses for what I said. Although I immediately removed that segment from my podcast, it still doesn't change the results. I know full well how much words can hurt people, having seen my wife get destroyed by the tabloids, and I am embarrassed that I didn't think before I spoke," he wrote. "Sometimes comedians go too far. I went too far. I cannot change what I said, but I can assure you that my heart is broken that I hurt her. I am very sorry."
He signed the blog post, "With the utmost sincerity, Jay Mohr."
"Apology accepted," Milano responded on Twitter, adding, "(She grunts while aggressively yet cautiously prying off her head-to-toe Spanx.) #PassTheCookies"
.@jaymohr37 So sorry you felt the need to publicly fat-shame me. Be well and God Bless. Please send my love to your beautiful wife.— Alyssa Milano (@Alyssa_Milano) December 26, 2013