The well known character actor passed away at his home on Friday at the age of 65, The Hollywood Reporter confirms.
TMZ reports his death comes after a long battle with skin cancer.
With a career spanning five decades, Philadelphia native Rebhorn was a familiar face to TV viewers in shows including White Collar, Law & Order and Seinfeld (he played the D.A. who sent Jerry and his friends to jail in the final episode of the show).
Moviegoers will remember him from roles in films including My Cousin Vinny, Basic Instinct and Cold Mountain.
"It's a sad day. I just learned James Rebhorn passed," Rebhorn's Independence Day director, Roland Emmerich, Tweeted. "Such a great talent and always a joy to work with. RIP."