Chelsea Handler will end her Chelsea Lately talk show at the end of 2014, her manager, Irving Azoff, told The Hollywood Reporter.
The bawdy comedian has helmed the E! show for the past eight years and serves as the lone female late-night host on cable and network television.
Azoff said she's exploring opportunities including a radio program or another late-night show on a different channel or digital service.
Handler's announcement comes less than three weeks after the release of her latest book, Uganda Be Kidding Me, her first to sit atop the New York Times bestseller list for more than a week.