After a protracted battle with progressive supranuclear palsy (PSP), actor and comedian Dudley Moore died on Wednesday at 11 a.m. at the age of 66, his publicist reported to the Associated Press. The British native began his performing career as a chorister and organist in his parish church in Dagenham, near London. In 1960, as an Oxford graduate, he joined the cast of the satirical revue "Beyond The Fringe," where he teamed up with comedian Peter Cook. The show, a hit in London, eventually crossed the pond to find success on Broadway. However, Moore didn't became a household name in America until his role opposite Bo Derek in the 1979 comedy "10," where he played a man obsessed with the perfect woman. He scored another box office hit two years later with "Arthur," portraying a wealthy drunk who finds meaning in a relationship with a coffee shop waitress, played by Liza Minnelli. In addition to his acting, Moore was also an accomplished pianist. "I can't imagine not having music in my life, playing for myself or for other people. If I was asked, 'Which would you give up,' I'd have to say acting," he said in an interview with the Associated Press in 1988. In his personal life, Moore's four marriages ended in divorce. He is survived by two sons, Patrick, 26, and Nicholas, 6.

Read PEOPLE.com's obituary of the actor.