With the long run of NBC's hit "Friends" winding to a close, Courteney Cox Arquette says she's ready for a new challenge: motherhood.

Like her small-screen character, Monica Geller, Cox Arquette been trying to have a child, the actress tells Barbara Walters in an interview slated to air on ABC's "20/20" on Friday night, the Associated Press reports. Cox Arquette says she has tried in vitro fertilization, and actually gets pregnant easily, but has had "many miscarriages."

The 39-year-old actress married David Arquette, 32, her "Scream" costar, in 1999. Although she says they'd consider adopting a child, she added, "I do want his genes, and I would try probably a surrogate before that."

"We're not panicked about it," she adds in a USA Today interview. "A lot of times people say as soon as you relax you'll have a kid. I'm not worried about it.''

The actress tells the paper that the couple are "committed to our great relationship. We're committed to growing and changing, and we give each other a lot of freedom," Cox Arquette says. "We have problems, don't get me wrong. But we would be in therapy and get it Fixed." She adds that they went to therapy "for a long time" before they got married.

Cox Arquette also is working with her actor hubby as co-executive producers on the new "Mix It Up," a design series on WE: Women's Entertainment that will take two people who live together and spend no more than $2,500 to come up with a style that works for them both.

The serial renovator has bought, redone and sold five houses in L.A. since 1986, the paper notes -- and although Cox Arquette says she will never sell the couple's Malibu beach house, her current home in the Hollywood Hills could wind up on the block at some point.