With his show's third season premiering Sept. 10 (8:30 p.m.), Lopez told PEOPLE about his early days on the stand-up scene, his comic heroes and his daughter's knack for the "Lopez put-down."
You were 18 years old when you started in stand-up. Tell us about your first time.
It was June 4, 1979, the first time I went on stage. I didn't know I could do it but I knew I couldn't not do it. I quit everything in my life and this was the one thing I couldn't quit. The first night was awful because I was so afraid, and I was never more afraid because it was going out of my character to be outgoing and to be vulnerable and to be out there and onstage. My hands were sweaty and I couldn't swallow, and I drank a bottle of wine to calm my nerves.
How did you refine your comedic skills?
I love comedy and I would write things to myself as an exercise in writing. I didn't do well for years, and I quit. I started to break down why I was afraid and started to look at people I admired, like Richard Pryor, Eddie Murphy, Freddie Prinze, George Carlin and all. I said, To get to where they are, they all have had to endure bad nights and it's not easy. If the worst thing that can happen is that nobody laughs, then I can deal with that, because the worst thing that can happen at the factory is that I could lose a limb or be crushed by a huge machine.
So I started to relax and would work on my act eight hours a day, sitting at a desk writing at my grandmother's house, and I would put on Richard Pryor Live on Long Beach and would play it like a loop and think and write.