Age at diagnosis: 36
After watching her mother battle cancer twice, Applegate was diagnosed with breast cancer in August 2008 and underwent a double mastectomy, even though cancer was detected in only one of her breasts. "Sometimes I cry. Sometimes I scream, and I get really angry," the actress, now cancer-free and the mother of a 4-year-old daughter, admitted on Good Morning America, adding, "I think it's all part of healing."