Cox stars in the teen-slasher flick Scream, which grosses more than $103 million domestically. While filming, Cox, 32, becomes close with costar David Arquette, 25. "I'm a little too wild for her," he tells PEOPLE at the time. "She deserves someone more together than I am." In September 1998, Arquette asks Cox to marry him.
Cox marries David Arquette in San Francisco's Grace Cathedral. Guests, including Brad Pitt and Friends costars Aniston, Perry and Kudrow, look on as she walks down the aisle to Paul McCartney's "Maybe I'm Amazed." The two exchange vows, with Cox wearing a one-of-a-kind Valentino dress.
Cox Arquette expands her repertoire, producing the comedy The Shrink Is In. She and husband David star. While the movie goes straight to video, Cox Arquette continues to produce several TV projects. A 2003 series, Mix It Up, incorporates one of her passions, home decorating.
After 10 seasons as one of America's most unforgettable sitcoms, Cox Arquette and her costars tape the final episode of Friends. Major waterworks and as costar and best friend Aniston calls it, "inevitable pain" ensue.
Cox and Arquette add a third member to the family with daughter Coco Riley Arquette. She is born in L.A. a day before the couple's fifth anniversary, reports PEOPLE. The healthy 6-lb. girl was conceived via in vitro fertilization and "is the best present they could have hoped for," a source close to the Arquettes tells PEOPLE. "It's been a long haul." The couple plans to have a second child.
Cox Arquette returns to the small screen to play an editor-in-chief of two tabloid magazines in the FX network drama Dirt. She and her husband both serve as executive producers for the show, which premieres to 3.7 million viewers. On the show's season finale in March, fellow Friends costar Jennifer Aniston guest stars as a rival magazine editor, who shares a much-publicized onscreen kiss with Cox Arquette.
Cox Arquette appears on the cover of Marie Claire, where she opens up about anti-aging cosmetic procedures–specifically Botox, which she says she "hated." The actress, whose FX series Dirt was cancelled after two seasons, hasn't ruled out future procedures, but has to clear that decision with her husband: "He loves the aging process. He thinks it's beautiful, [so] I'm under pressure to not do anything."
Cox Arquette returns to primetime with a guest stint on Scrubs as chief of medicine Dr. Maddox in the show's final season. The actress, who has a development deal with ABC Studios, also returns to the small screen in September as executive producer and star of Cougar Town, playing a newly-single 40-year-old mother.
After 11 years of marriage, Cox and Arquette announce they're separating. "The reason for this separation is to better understand ourselves and the qualities we need in a partner and for our marriage," says the estranged couple. "We remain best friends and responsible parents to our daughter and we still love each other deeply." In June 2012, Cox and Arquette each file for divorce on the same day, and their split is finalized a year later.
After more than a decade, Cox reprises her role as newsmaker Gale Weathers in Scream 4. "I just enjoy doing all three of them. That’s where I met David," Cox tells EW. "Each Scream represents a huge turning point in my life: I met David on 1. We did not like each other on 2. We got married right before on 3." With a host of new (Emma Roberts, Hayden Panettiere) and old faces (Neve Campbell, David Arquette), the fourth installment of the horror franchise opens at No. 2, making nearly $20 million at the box office.
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