1996

December 18

It's A Scream

Cox stars in the teen-slasher flick Scream, which grosses more than $103 million domestically. While filming, Cox, 32, becomes close with costar David Arquette, 25. "I'm a little too wild for her," he tells PEOPLE at the time. "She deserves someone more together than I am." In September 1998, Arquette asks Cox to marry him.

1999

Courteney Cox Arquette

June 12

Tying the Knot

Cox becomes Cox Arquette when she marries David Arquette in San Francisco's Grace Cathedral. Guests, including Brad Pitt and Friends costars Aniston, Perry and Kudrow, look on as she walks down the aisle to Paul McCartney's "Maybe I'm Amazed." The two exchange vows, with Cox Arquette wearing a one-of-a-kind Valentino dress.

2001

Courteney Cox Arquette

November

Mass Production

Cox Arquette expands her repertoire, producing the comedy The Shrink Is In. She and husband David star. While the movie goes straight to video, Cox Arquette continues to produce several TV projects. A 2003 series, Mix It Up, incorporates one of her passions, home decorating.

2004

Courteney Cox Arquette

January 23

Farewell Friends

After 10 seasons as one of America's most unforgettable sitcoms, Cox Arquette and her costars tape the final episode of Friends. Major waterworks and as costar and best friend Aniston calls it, "inevitable pain" ensue.

Courteney Cox Arquette

June 13

Welcome, Coco

The Cox Arquettes add a third member to the family with daughter Coco Riley Arquette. She is born in L.A. a day before the couple's fifth anniversary, reports PEOPLE. The healthy 6-lb. girl was conceived via in vitro fertilization and "is the best present they could have hoped for," a source close to the Arquettes tells PEOPLE. "It's been a long haul." The couple plans to have a second child.

2005

August 25

Auction Hero

Cox Arquette organizes an auction for the family of Natalee Holloway, an Alabama teen who attended her former high school and who disappeared three months earlier under suspicious circumstances while vacationing in Aruba. The 200 items Cox Arquette auctions off help raise $110,000 to aid in covering the legal fees and travel expenses of Holloway's family.

2007

Courteney Cox Arquette

January 01

A Dirty Return

Cox Arquette returns to the small screen to play an editor-in-chief of two tabloid magazines in the FX network drama Dirt. She and her husband both serve as executive producers for the show, which premieres to 3.7 million viewers. On the show's season finale in March, fellow Friends costar Jennifer Aniston guest stars as a rival magazine editor, who shares a much-publicized onscreen kiss with Cox Arquette.

2008

Courteney Cox Arquette

November

Courteney Dishes on Botox

Cox Arquette appears on the cover of Marie Claire, where she opens up about anti-aging cosmetic procedures–specifically Botox, which she says she "hated." The actress, whose FX series Dirt was cancelled after two seasons, hasn't ruled out future procedures, but has to clear that decision with her husband: "He loves the aging process. He thinks it's beautiful, [so] I'm under pressure to not do anything."

Photo Credits

BIOGRAPHY (top to bottom): MICHAEL TAMMARO/AP; Women's Entertainment/Everett; PHOTOFEST; Kevin Mazur/WireImage; FX

Edited by Mai Dinh, Janet Murphy