Breakout Stars of the Year

They stood out from the pack in '05. We can't wait to see what happens next ...


Why do we love the season's hottest new show? Let's look at how each character operates: Dr. Derek "McDreamy" Shepherd (Patrick Dempsey, far right) has his hair; Dr. Meredith Grey (Ellen Pompeo, to his left), her heart; Dr. Christina Yang (Sandra Oh), her mouth; Dr. Alex Karev (Justin Chambers), testosterone; Dr. Izzie Stevens (Katherine Heigl), estrogen; and finally, Dr. George O'Mally (T.R. Knight) – the eyes.