From George Clooney to Julia Roberts: The Best Guest Stars on Friends

It may be all about the core six, but the gang had many famous faces join them along the way

SUSAN SARANDON

Joey gets a second chance at soap stardom in the season 7 episode, "The One with Joey's New Brain," after he learns that his character Dr. Drake Ramoray, who had been in a coma for five years, is getting a new brain. Said new brain comes from Sarandon's Jessica Lockhart, a veteran soap star and egomaniac.