From George Clooney to Julia Roberts: The Best Guest Stars on Friends

It may be all about the core six, but the gang had many famous faces join them along the way


Rachel spends the better part of the season 7 episode "The One with Rachel's Big Kiss" trying to convince everyone she kissed her sorority sister Melissa, played by Ryder, in college. (Spoiler: She did – and Melissa remembers it fondly.)