Tom & Penelope: The Romance Ends

After three years as a couple – with a great deal of time spent apart on film sets – Tom Cruise and Penelope Cruz have called it quits. "They broke up at the end of January and it's amicable," Lee Anne DeVette, Cruise's sister and publicist, tells PEOPLE. Take a look back at highlights of the couple's romance.

Ready, Set, Action!

Tom Cruise and Penelope Cruz met on the Vanilla Sky set (in New York City in 2000), but despite their onscreen heat and rumors of an on-set romance, both denied that their relationship was anything more than professional. At the time, Cruise was still married to Nicole Kidman.