Becoming ... Jennifer Aniston

Though she bid a tearful adieu to Friends, Jennifer Aniston has plenty to smile about. The actress says she's looking forward to her next project: starting a family. See the defining moments in the life of PEOPLE's Most Beautiful cover girl. By Serena Kappes

6 of 11

REAL SIMPLE

Always perfectly coiffed on the red carpet (as with Pitt at the 2000 Emmys), in everyday life Aniston has a low-key style. "She's no different than the person she was 15 years ago," pal Kathy Najimy told PEOPLE. "Her clothes are the exact same, her T-shirts, her little tank tops, her cargo pants and her flip-flops."