1976

The Bionic Baby

Days of Our Lives's John Aniston (he plays villain Victor Kiriakis) and his wife Nancy enroll their 6-year-old daughter Jennifer in Manhattan's Rudolf Steiner School, which encourages students to refrain from watching TV and movies. When Aniston's half brother, John Melick, babysits, she sneaks in episodes of The Bionic Woman. "She'd make that ba-na-na-na-na sound effect around the house, running around directing herself in scenes from the show," Melick tells PEOPLE in 1997. "I guess she was destined for television."

1993

Jennifer Aniston

January

Not So Lucky Break

After skipping college to wait tables and pursue acting in New York, Aniston appears in the horror flick Leprechaun. But there it's no pot of gold: The film pulls in just $8.5 million. However, her luck changes the following year when she reads for a new sitcom called Friends. She lands the part of Rachel Green just three hours after her audition.

1995

Jennifer Aniston

December 25

Hair-Do

Aniston's layered haircut dubbed "The Rachel," after her Friends character, launches a national trend. "It's bizarre," 26-year-old Aniston tells PEOPLE in December. "I keep thinking, 'Wait – it's just me!' "

1996

February

Mommy Dearest

Aniston's mother, Nancy, gives an interview about her famous daughter, commenting on Friends and "The Rachel" to a tabloid TV show, which leads to her estrangement with her daughter. Their relationship will further be severed when Nancy writes a book about their mother-daughter relationship in 1999.

Jennifer Aniston

August

Romance in the Air

Aniston shares the screen with Edward Burns and Cameron Diaz in She's the One. It will be the first in a string of romantic comedies for the actress, including Picture Perfect and The Object of My Affection with Paul Rudd. But it isn't until 1999's cult classic Office Space that Aniston brings her real comedic chops.

1998

November 02

Red-Carpet Shuffle

The actress and her reported love interest, Brad Pitt, set a red-carpet trend for future celebrity couples: At the premiere of Pitt's Meet Joe Black the stars arrive in separate limos to avoid being photographed together.

2000

Jennifer Aniston

July 29

Jen & Brad: "I Do"

In a top-secret Malibu ceremony, Aniston and Pitt wed. Aniston promises to always make her husband's "favorite banana milkshake" in front of their 200 guests. The wedding costs an estimated $1 million which includes 50,000 flowers, four bands, Dom Perignon and fireworks. The newlyweds go on to purchase a $13.5 million five-bedroom Beverly Hills estate complete with wine cellar and screening room. They spend millions renovating it, despite different design tastes. (Aniston later admits that she never cared for Pitt's modern design style.)

2002

Jennifer Aniston

January

Good Times

Aniston receives glowing reviews at Sundance for her un-Rachel-like role in the indie hit The Good Girl, costarring Jake Gyllenhaal.

Jennifer Aniston

September 22

Aniston Wins an Emmy

In its ninth season, Friends wins the Emmy for Outstanding Comedy and Aniston takes home the Best Lead Actress statuette for the first time. Aniston's long wait for an Emmy was prolonged by stammering presenter Bob Newhart. "It felt like a year," she tells PEOPLE. "I thought maybe it was going to be somebody else."

2004

Jennifer Aniston

January 23

End of an Era

After ten years on one of America's most unforgettable sitcoms, Aniston and her costars tape the final episode of Friends. Major waterworks and as Aniston calls it, "inevitable pain" ensue.

Photo Credits

BIOGRAPHY (top to bottom): Trimark Pictures/Photofest; Everett; 20th Century Fox/Everett; AP; Everett Collection; Fitzroy Barrett/GLOBE; PHOTOFEST

Edited by Mai Dinh, Janet Murphy